Abstract

Identification and subsequent isolation of anti-dengue active compounds in medicinal plants are potentially useful for developing antiviral chemical analogues. This study investigated the potential use of aqueous, methanolic, and ethanolic extracts of Syzygium sp. “O-on” against bacterial co-infection of Staphylococcus aureus and Pseudomonas aeruginosa in dengue. Taxonomic identification of Syzygium sp. “O-on” collected from Mindanao signifies possible new species through their distribution, ecology and conservation status. Phytochemical analysis showed that crude aqueous and organic solvent extracts contain medicinally important bioactive compound. Highest antimicrobial potentials were observed for the methanolic extracts of Syzygium sp. which inhibited 62.5 and 51.16% of the tested microorganisms, respectively, with higher activity against antibiotic-resistant bacteria (83.3%). We suggest that the Syzygium sp. could be potentially exploited to control the behaviors of this pathogen as well as for its utilization as a lead compound in screening for anti-dengue agents based on new antimicrobial targets.