Davao City, a major urban center in the Philippines with its various landforms and population distribution has been affected by COVID-19. This study aimed to identify and locate areas with COVID-19 cases in Davao City, create a location map of COVID-19 cases in Davao City and determine association between number of COVID-19 cases and population density. Data were obtained from the Philippines Statistics Authority, Davao City LGU and, the Department of Health Davao Region. QGIS application was used to generate location maps of COVID-19 cases and Pearson r correlation was the statistical method used. Most of the COVID-19 occurrence are in Poblacion, Talomo, Agdao and Buhangin. areas with high population densities record the high occurrence of COVID-19 cases There is a high correlation between number of COVID-19 infection and population densities for this study. This indicates that dense population may have contributed to the spread of the COVID-19 infection in the city. The occurrence of population densities in Davao City should be addressed to prevent public health threats brought about by infectious diseases such as COVID-19.